Les hypnotiques Z doivent être réservés aux insomnies occasionnelles et être prescrits (Liste 1) pendant seulement quelques jours.
La zopiclone provoque une conduite avec facultés affaiblies semblable à celle des benzodiazépines. Les utilisateurs à long terme de médicaments hypnotiques pour les troubles du sommeil acquièrent une tolérance partielle aux effets néfastes sur la conduite, même après un an d’utilisation, entraînant toujours une augmentation du taux d’accidents de la route [17]. Les patients qui conduisent des véhicules motorisés ne doivent pas prendre de zopiclone sauf s'ils arrêtent de conduire en raison d'un risque d'accident considérablement accru chez les utilisateurs de zopiclone. [18] La zopiclone induit une altération de la fonction psychomotrice. [19] [20] La conduite ou l'utilisation de machines doivent être évitées après la prise de zopiclone, car leurs effets peuvent se prolonger jusqu'au lendemain, y compris en cas de troubles de la coordination œil-main. [21] [22]
La zopiclone provoque une conduite avec facultés affaiblies semblable à celle des benzodiazépines. Les utilisateurs à long terme de médicaments hypnotiques pour les troubles du sommeil acquièrent une tolérance partielle aux effets néfastes sur la conduite, même après un an d’utilisation, entraînant toujours une augmentation du taux d’accidents de la route [17]. Les patients qui conduisent des véhicules motorisés ne doivent pas prendre de zopiclone sauf s'ils arrêtent de conduire en raison d'un risque d'accident considérablement accru chez les utilisateurs de zopiclone. [18] La zopiclone induit une altération de la fonction psychomotrice. [19] [20] La conduite ou l'utilisation de machines doivent être évitées après la prise de zopiclone, car leurs effets peuvent se prolonger jusqu'au lendemain, y compris en cas de troubles de la coordination œil-main. [21] [22]
Some quotes
Conclusions:
Ramelteon (8 mg) and zopiclone (7.5 mg) significantly impaired driving performance, cognitive, memory, and psychomotor performance the morning following bedtime administration. In contrast to zopiclone, ramelteon produced no balance impairments.
To summarize, results of the present study indicate that driving performance is mildly impaired in insomnia patients after evening administration of zopiclone 7.5 mg at least until 11 h after intake. Chronic use of hypnotics seems to attenuate the severity of effects of zopiclone 7.5 mg. Nevertheless, this reduction does not result in an absence of impairing effects in insomnia patients chronically using hypnotics. The magnitude of effects found in the infrequent users group was slightly smaller than found in previous studies investigating residual effects of zopiclone 7.5 mg in healthy, younger volunteers. This suggests that investigating residual effects of hypnotics in healthy volunteers may yield a minor overestimation of the actual effects in insomnia patients who start using hypnotics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072058/
The most frequently prescribed hypnotics were zolpidem (57.1%, 80/140) and zopiclone (27.8%, 39/140).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845506/#!po=10.7843
Results: Fourteen studies, published from 1984 to 2013 (295 subjects), were included in this meta-analysis. Overall, significant impairment was found when morning testing (i.e., 10–11 h after initiating sleep) was compared to afternoon testing (i.e., 16–17 h after initiating sleep; P = .0001). Twice the standard dose also showed significant impairment (P = .0001) relative to the standard dose. The time of the test, morning versus afternoon, also had an impact on individual drugs. Middle of the night administration (MOTN) of zolpidem and zopiclone caused significant impairment the following morning, though no such impairment was seen with zaleplon. Finally, half-life was also assessed (short: <6 6="" h="" intermediate:="" long:="">12 h) and both intermediate- and long-acting drugs caused significant impairment the morning after bedtime administration, whereas short acting hypnotics did not.
Conclusions: These analyses indicate that the half-life, dose of the hypnotic, as well as time between treatment and driving, as measured by SDLP, all significantly impact the ability to drive a car after taking hypnotic drugs.https://www.tandfonline.com/doi/full/10.1080/15389588.2013.830211
No gender differences
https://www.ncbi.nlm.nih.gov/pubmed/22607251
The most frequently prescribed hypnotics were zolpidem (57.1%, 80/140) and zopiclone (27.8%, 39/140).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845506/#!po=10.7843
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| https://doi.org/10.1002/hup.2603 |
Results: Fourteen studies, published from 1984 to 2013 (295 subjects), were included in this meta-analysis. Overall, significant impairment was found when morning testing (i.e., 10–11 h after initiating sleep) was compared to afternoon testing (i.e., 16–17 h after initiating sleep; P = .0001). Twice the standard dose also showed significant impairment (P = .0001) relative to the standard dose. The time of the test, morning versus afternoon, also had an impact on individual drugs. Middle of the night administration (MOTN) of zolpidem and zopiclone caused significant impairment the following morning, though no such impairment was seen with zaleplon. Finally, half-life was also assessed (short: <6 6="" h="" intermediate:="" long:="">12 h) and both intermediate- and long-acting drugs caused significant impairment the morning after bedtime administration, whereas short acting hypnotics did not.
Conclusions: These analyses indicate that the half-life, dose of the hypnotic, as well as time between treatment and driving, as measured by SDLP, all significantly impact the ability to drive a car after taking hypnotic drugs.https://www.tandfonline.com/doi/full/10.1080/15389588.2013.830211
No gender differences
https://www.ncbi.nlm.nih.gov/pubmed/22607251
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