21 trisomy

http://blogs.plos.org/biologue/2015/02/24/chromosome-biology-youve-come-a-long-way-baby/

http://www.sciencedirect.com/science/article/pii/S0149763416301567

Highlights

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Down syndrome (DS) is the commonest genetic cause of mental disability.

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Epigenetic modifications are implicated in neurocognitive dysfunction in DS.

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These epigenetic modifications are suitable therapeutic targets, but current therapies may have unwanted side effects.

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CRISPR-Cas9 is a precise genome editing technology that could be used to target epigenomic abnormalities in DS.

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A number of barriers − both technical and ethical − will need to be overcome for clinical translation.

https://www.nature.com/news/should-you-edit-your-children-s-genes-1.19432