"The salient findings of this study are that long-term exposure to proton pump inhibition: 1) impairs
lysosomal acidification and enzyme activity, in association with protein aggregate accumulation; 2)
increases the generation of reactive oxygen species, and impairs the NO synthase pathway; 3) accelerates
telomere erosion in association with reduced expression of the shelterin complex; and 4) speeds endothelial
aging as manifested by impaired cell proliferation and angiogenesis, together with histological markers of
senescence and endothelial-to-mesenchyme transition. Our results in primary human EC are consistent with
the recent finding that PPIs impair the activity of lysosomal enzymes in several immortalized cell lines
including A549, Caco2, HEK293, and HepG2.15 Lysosomes bind to autophagosomes to complete the
process of autophagy,29 which comprises the degradation and elimination of unwanted cellular products
including misfolded proteins.14, 15 An impairment of lysosomal acidification and reduced lysosomal enzyme
activity might be expected to result in an accumulation of protein aggregates."
When you have 94 retractions, what’s two more?
Il y a 1 heure