samedi 23 avril 2016

Repartition for retirement pensions is a conceptual lie and a deadly operation

http://blogs.wsj.com/moneybeat/2016/04/08/you-not-the-government-are-responsible-for-your-retirement-savings/?shareToken=st6261e10e5dc44570b3e2691714d9a9cd%3Fmod%3De2fb&cb=logged0.40379089835707704

Darwinian conception of social constructions

http://eprints.lse.ac.uk/36719/1/Darwinian%20evolutionary%20theory(lsero).pdf

Disruption of drug business? The one shot treatment of PCSK9 for lowering LDLc by CRISPR-Cas9

http://www.nature.com/nature/journal/v520/n7546/abs/nature14299.html

The RNA-guided endonuclease CRISPR-Cas9 is being widely adopted as the genome-editing tool of choice. However, the physical size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) poses problems for applications that use the adeno-associated virus (AAV) as a delivery vehicle. Feng Zhang and colleagues now characterize six smaller Cas9 orthologues. Focusing on Cas9 fromStaphylococcus aureus, they packaged it and its single guide RNA expression cassette into a single AAV vector and targeted the cholesterol regulatory gene Pcsk9 in the mouse liver. Greater than 40%gene modification was observed within a week of injection, accompanied by significant reductions in serum Pcsk9 and total cholesterol levels.

CRISPR and xeno-transplantation

http://www.nature.com/news/new-life-for-pig-to-human-transplants-1.18768


http://journal.frontiersin.org/article/10.3389/fgene.2016.00047/full

April versus US government: end of the game?

http://www.wsj.com/articles/federal-prosecutors-drop-court-case-to-force-apple-to-unlock-iphone-1461377642
 
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