PCSK9 and atheroma reduction

http://www.medscape.com/viewarticle/871910?src=wnl_tp10n_161216_mscpedit_ous&impID=1254682

Bosch J et al. The effect of blood pressure and cholesterol lowering on cognition. American Heart Association 2016 Scientific Sessions. November 13, 2016; New Orleans, LA. Abstract

Hypothesis: Without repairing intimal damage you have to go at very low level of lipoprotein particles to reduce the plaque.
Glycocalyx and endothelial cells are badly damaged by several agressions which are the initial steps of plaque formation.