Depression: news for intractable ones

http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2016.15111500?journalCode=ajp

http://www.post-gazette.com/news/health/2016/08/22/Pittsburgh-researchers-may-have-found-cure-for-some-untreatable-depression/stories/201608220015

a Folinic acid (5-formyl-THF) enters the pathway without the action of DHFR and contributes active metabolites. 5-Methyl-THF is a distal metabolite. DHFR=dihydrofolate reductase; DHF=dihydrofolate; dTMP=deoxy-thymidine phosphate; dUMP=deoxy-uridine phosphate; NAD=nicotinamide adenine dinucleotide; NADP=nicotinamide adenine dinucleotide phosphate; NADPH=nicotinamide adenine dinucleotide phosphate, reduced; THF=tetrahydrofolate.