samedi 7 décembre 2013
vendredi 6 décembre 2013
Thank you Dr Nissen
i don't agree with all your assertions but some of them are so obvious...
I love the contra Flynn effect of watching TV!
http://www.medpagetoday.com/PracticeManagement/PracticeManagement/43257?
I love the contra Flynn effect of watching TV!
http://www.medpagetoday.com/PracticeManagement/PracticeManagement/43257?
Paying bone marrow donors?
http://www.medpagetoday.com/HematologyOncology/Hematology/43270?
My answer is yes. This is a renewable organ and payment could improve the status of patients who die because of organ shortage.
My answer is yes. This is a renewable organ and payment could improve the status of patients who die because of organ shortage.
Les paroles qui guérissent les haines sont plus importantes que les accents belliqueux de ceux qui croient à la guerre sainte
Nelson Mandela (1918-2013)
"As I walked out the door toward the gate that would lead to my freedom, I knew if I didn't leave my bitterness and hatred behind, I'd still be in prison."
jeudi 5 décembre 2013
Sex differences in the brain: what we observed in the daily life and brain wiring
Sex differences in the structural connectome of the human brain
- Madhura Ingalhalikara,1,
- Alex Smitha,1,
- Drew Parkera,
- Theodore D. Satterthwaiteb,
- Mark A. Elliottc,
- Kosha Ruparelb,
- Hakon Hakonarsond,
- Raquel E. Gurb,
- Ruben C. Gurb, and
- Ragini Vermaa,2
- Edited by Charles Gross, Princeton University, Princeton, NJ, and approved November 1, 2013 (received for review September 9, 2013)
Significance
Sex differences are of high scientific and societal interest because of their prominence in behavior of humans and nonhuman species. This work is highly significant because it studies a very large population of 949 youths (8–22 y, 428 males and 521 females) using the diffusion-based structural connectome of the brain, identifying novel sex differences. The results establish that male brains are optimized for intrahemispheric and female brains for interhemispheric communication. The developmental trajectories of males and females separate at a young age, demonstrating wide differences during adolescence and adulthood. The observations suggest that male brains are structured to facilitate connectivity between perception and coordinated action, whereas female brains are designed to facilitate communication between analytical and intuitive processing modes.
Abstract
Sex differences in human behavior show adaptive complementarity: Males have better motor and spatial abilities, whereas females have superior memory and social cognition skills. Studies also show sex differences in human brains but do not explain this complementarity. In this work, we modeled the structural connectome using diffusion tensor imaging in a sample of 949 youths (aged 8–22 y, 428 males and 521 females) and discovered unique sex differences in brain connectivity during the course of development. Connection-wise statistical analysis, as well as analysis of regional and global network measures, presented a comprehensive description of network characteristics. In all supratentorial regions, males had greater within-hemispheric connectivity, as well as enhanced modularity and transitivity, whereas between-hemispheric connectivity and cross-module participation predominated in females. However, this effect was reversed in the cerebellar connections. Analysis of these changes developmentally demonstrated differences in trajectory between males and females mainly in adolescence and in adulthood. Overall, the results suggest that male brains are structured to facilitate connectivity between perception and coordinated action, whereas female brains are designed to facilitate communication between analytical and intuitive processing modes.
Footnotes
- 1M.I. and A.S. contributed equally to this work.
- 2To whom correspondence should be addressed. E-mail: ragini.verma@uphs.upenn.edu.
- Author contributions: M.I., T.D.S., H.H., R.E.G., R.C.G., and R.V. designed research; A.S., M.A.E., K.R., and H.H. performed research; A.S. and D.P. analyzed data; and M.I., R.E.G., R.C.G., and R.V. wrote the paper.
- The authors declare no conflict of interest.
- This article is a PNAS Direct Submission.
- Data deposition: The data reported in this paper have been deposited in the dbGaP database,www.ncbi.nlm.nih.gov/gap (accession no. phs000607.v1.p1).
Hair regeneration
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
- Claire A. Higginsa,
- James C. Chenb,c,
- Jane E. Cerisea,
- Colin A. B. Jahodad,1, and
- Angela M. Christianoa,b,1
- Edited by Zena Werb, University of California, San Francisco, CA, and approved September 5, 2013 (received for review May 28, 2013)
Significance
Growth of de novo hair follicles in adult skin occurs by a process known as hair neogenesis. One way of initiating neogenesis is to place dermal papillae isolated from the hair follicle in contact with an overlying epidermis where they reprogram the epidermis to adopt a follicular fate. This approach, however, has not been successful using cultured human dermal papilla cells in human skin because the cells lose their ability to induce hair growth after expansion in vitro. In this paper, we demonstrate that by manipulating cell culture conditions to establish three-dimensional papilla spheroids, we restore dermal papilla inductivity. We also use several systems biology approaches to gain a comprehensive understanding of the molecular mechanisms that underlie this regenerative process.
Abstract
De novo organ regeneration has been observed in several lower organisms, as well as rodents; however, demonstrating these regenerative properties in human cells and tissues has been challenging. In the hair follicle, rodent hair follicle-derived dermal cells can interact with local epithelia and induce de novo hair follicles in a variety of hairless recipient skin sites. However, multiple attempts to recapitulate this process in humans using human dermal papilla cells in human skin have failed, suggesting that human dermal papilla cells lose key inductive properties upon culture. Here, we performed global gene expression analysis of human dermal papilla cells in culture and discovered very rapid and profound molecular signature changes linking their transition from a 3D to a 2D environment with early loss of their hair-inducing capacity. We demonstrate that the intact dermal papilla transcriptional signature can be partially restored by growth of papilla cells in 3D spheroid cultures. This signature change translates to a partial restoration of inductive capability, and we show that human dermal papilla cells, when grown as spheroids, are capable of inducing de novo hair follicles in human skin.
Footnotes
- 1To whom correspondence may be addressed. E-mail: amc65@columbia.edu or colin.jahoda@durham.ac.uk.
- This Feature Article is part of a series identified by the Editorial Board as reporting findings of exceptional significance.
- Author contributions: C.A.H., C.A.B.J., and A.M.C. designed research; C.A.H., J.C.C., and J.E.C. performed research; C.A.H., C.A.B.J., and A.M.C. analyzed data; and C.A.H., C.A.B.J., and A.M.C. wrote the paper.
- The authors declare no conflict of interest.
- This article is a PNAS Direct Submission.
- Data deposition: The data reported in this paper have been deposited in the Gene Expression Omnibus (GEO) database, www.ncbi.nlm.nih.gov/geo (accession no. GSE44765).
- See Commentary on page 19658.
- This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1309970110/-/DCSupplemental.
mercredi 4 décembre 2013
GDP and GDP per capita
http://en.wikipedia.org/wiki/List_of_countries_by_GDP_(PPP)_per_capita
That's the number which is important for citizens!
http://en.wikipedia.org/wiki/List_of_countries_by_GDP_(nominal)
That's the number which is important for economic perspectives and consequences of recession.
The brits have the potential to overtake us!
That's the number which is important for citizens!
http://en.wikipedia.org/wiki/List_of_countries_by_GDP_(nominal)
That's the number which is important for economic perspectives and consequences of recession.
The brits have the potential to overtake us!
The bitter truth about PISA (big buzz now) and GDP...
 |
| According to this author the link is far more potent than previously thought by Lynn. it's a link with log(GDP)! |
An easily remembered relationship is obtained by considering the effect of a 10 point increase in IQ:
http://www.sciencedirect.com/science/article/pii/S0160289605001078#
IQ is measured as follows
IQ is measured as follows
 |
| PISA scores are in keeping with IQ distribution over the world |
Transparence pour les autres, F Hollande décidément pas très clair.
«On a tout fait pour garder le secret à l'époque», a confié à Europe 1 l'un des proches du président pour qui «rendre publique une opération, et de la prostate qui plus est, aurait été suicidaire». «On aurait eu des articles sur sa fatigue, sa faiblesse, sa maladie. C'était fini», tranche ce fidèle du président. D'autant plus que François Hollande, en plein régime, avait déjà perdu dix kilos à ce moment-là et présentait un visage émacié.
http://www.lefigaro.fr/politique/2013/12/04/01002-20131204ARTFIG00261-hollande-opere-de-la-prostate-avant-d-etre-candidat-a-la-primaire-ps.php?m_i=9u_9FioYwjfHibQdRHaYtYQLUxVnb_BMLPp5wVU8PMr6MPODD
http://www.reuters.com/article/2013/12/04/france-president-prostate-idUSL5N0JJ20920131204
http://www.lefigaro.fr/politique/2013/12/04/01002-20131204ARTFIG00261-hollande-opere-de-la-prostate-avant-d-etre-candidat-a-la-primaire-ps.php?m_i=9u_9FioYwjfHibQdRHaYtYQLUxVnb_BMLPp5wVU8PMr6MPODD
http://www.reuters.com/article/2013/12/04/france-president-prostate-idUSL5N0JJ20920131204
La plus fausse bonne solution: étatiser la sécu!
Ils veulent plus d'état id est un Service Public de Soins, SPS qu'ils baptiseront Service Public de Santé car cela fait mieux la maladie étant tabou dans la novlangue postmoderne. Cette agence ferait soi disant des économies...
On peut très légitimement en douter car les énarques n'ont fait montre jusqu'à présent que d eleur capacité à dépenser, faire fonctionner France Trésor avec des offres d'OAT et laisser filer les déficits.
http://www.lefigaro.fr/conjoncture/2013/12/03/20002-20131203ARTFIG00558-le-rapport-qui-veut-supprimer-l-assurance-maladie.php?m_i=jGkjTEffVTKbXurOWuX1CJFGVuLO3nLUKYuhYC3gZWh9E1vPK
On peut très légitimement en douter car les énarques n'ont fait montre jusqu'à présent que d eleur capacité à dépenser, faire fonctionner France Trésor avec des offres d'OAT et laisser filer les déficits.
http://www.lefigaro.fr/conjoncture/2013/12/03/20002-20131203ARTFIG00558-le-rapport-qui-veut-supprimer-l-assurance-maladie.php?m_i=jGkjTEffVTKbXurOWuX1CJFGVuLO3nLUKYuhYC3gZWh9E1vPK
mardi 3 décembre 2013
Deflation
Producer prices declined more than forecast in October, highlighting the deflationary risks facing the euro-zone economy. With consumer price inflation already barely positive, the absence of pipeline pricing pressure contained in this indicator gives the European Central Bank plenty of justification to add more liquidity. Whether its board members feel politically and technically able to ease policy when they meet on Thursday is another matter. (AM)
Dommage que le rapport PISA ne sonde pas la satisfaction des profs!
Il parait que nous avons perdu des places au classement mondial...
C'est secondaire car les décisions des gouvernants depuis longtemps ne concernent que la satisfaction des profs.
Donc ça coute plus cher et les résultats des élèves régressent.
Rien de surprenant.
Le mammouth continue à grossir et à rugir car il ne mange pas assez.
Circulez les élèves vous troublez le repos de la bête.
C'est secondaire car les décisions des gouvernants depuis longtemps ne concernent que la satisfaction des profs.
Donc ça coute plus cher et les résultats des élèves régressent.
Rien de surprenant.
Le mammouth continue à grossir et à rugir car il ne mange pas assez.
Circulez les élèves vous troublez le repos de la bête.
lundi 2 décembre 2013
Pill and female sexual function
Original Research
Hormonal Contraception and Female Pain, Orgasm and Sexual Pleasure
Article first published online: 29 NOV 2013
DOI: 10.1111/jsm.12409
© 2013 International Society for Sexual Medicine
Issue
